LabEx Medalis

Medalis : Équipe PARIDG de l'IrebsBiotechnologie et signalisation cellulaire
UMR 7242

Institut de recherche de l'École de biotechnologie de Strasbourg (Irebs

Pôle API du Parc d'innovation d'Illkirch
Boulevard Sébastien Brant - BP10413
67412 ILLKIRCH Cedex - France

Phone: +33 368 854 704 - Fax: +33 638 854 683

Website
Medalis: Team Poly(ADP-ribosyl)ation and genome integrity

Main investigators

Medalis : Schreiber ValérieDr. Valérie SCHREIBER

Research Director at CNRS

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Medalis : Dantzer FrançoiseDr. Françoise DANTZER

Research Director at CNRS

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Presentation

Our aim is to decipher the complex role of poly(ADP-ribosyl)ation reactions in the mechanisms governing genome stability and tumorigenesis. Regulation of poly(ADP-ribose) produced by PARPs in response to DNA damages and degraded by PARG is critical for the outcome of the damaged cell.
PARP-1 inhibitors are already engaged in clinical trials for the treatment of certain cancers. Our recent data have revealed an essential role of PARP-3 and PARG in the DNA damage response and in mitotic progression, designing these two enzymes as potential therapeutic targets in cancer therapies.
Medalis : Équipe Poly(ADP-ribosyl)ation et intégrité du génome
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